[Effects of lead poisoning on properties of brain mitochondria in young rats].

When the litters were 14 days old, wistar rat pups received lead ions. The suckling mother was fed by a powdered laboratory chow containing lead carbonate (1%, 2%, 4%). The intoxication was going on for 3 days to 9 weeks.

Effects of manganese ions on thyroid function in rat.

Rats were treated with MnSO4, H2O (1 mg/100 g/day, SC) for a period of 5 weeks. Thyroxine (T4) and triiodothyronine (T3) levels were measured in thyroid by radioimmunoassay. T4, T3 and thyroid-stimulating hormone (TSH) levels were also estimated by radioimmunoassay in serum.

[The effect of Mn2+ on thyroid iodine metabolism in rats].

Injection into rats of manganous chloride (2 mg/100 g) showed, after a 24-hr period, a marked depression of thyroidal 131I uptake. There is a decrease in serum T3 and T4 levels and an increase in I- level. These results demonstrate that the action of manganous ions is to block uptake of I- by the thyroid.