Humans spend much of their lives in conversation, where they tend to hold many simultaneous motives. We examine two fundamental desires: to be responsive to a partner and to disclose about oneself. We introduce one pervasive way people attempt to reconcile these competing goals--a sequence in which individuals first pose a question to their conversation partner ("How was your weekend?"), let their partner answer, and then answer the question themselves ("Mine was amazing!").
View Article and Find Full Text PDFBackground: Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer-related morbidity and mortality in children and young adults. These cancers share common challenges, including high rates of metastasis, recurrence or treatment resistance, leading to a 5-year survival rate of approximately 20% for patients with advanced disease stages. Despite the critical need, therapeutic advancements have been limited over the past three decades.
View Article and Find Full Text PDFThe Immunization Agenda 2030 (IA2030) has been endorsed at the World Health Assembly as the world's strategy for immunization. The Movement for IA2030 is a voluntary collective of immunization practitioners, principally from low- and middle-income countries, who have pledged to support each other to accelerate local action in support of this global strategy. Collective action is facilitated by the peer learning platform established by The Geneva Learning Foundation (TGLF).
View Article and Find Full Text PDFAutosomal-dominant variants in the CPT1C gene have been associated with hereditary spastic paraplegia type 73 (SPG73), which typically presents with slowly progressive lower limb weakness and spasticity and is therefore considered a pure form of hereditary spastic paraplegia. However, we report two unrelated males with novel CPT1C variants (NM_001199753.2: patient 1: c.
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