Publications by authors named "A M Bold"
γδ T cells, with their properties of both the innate and acquired immune systems, are suitable candidates for cellular immunotherapy in cancer. Because of their non-major histocompatibility complex (MHC) binding T cell receptor, allogenic transfer is feasible without relevant graft versus host reactions. In recent years, much experience has been gained with expansion and stimulation of γδ T cells using bisphosphonates and Interleukin 2.
View Article and Find Full Text PDFArticle Synopsis
- Researchers explored the reaction of red phosphorus with alkyl bromides using strong bases and phase transfer catalysts to create sulfur-containing organophosphorus compounds that function as extractants for heavy metals.
- The reaction conditions involved heating the mixture and then adding elemental sulfur, resulting in a range of products, primarily alkylphosphines and their oxides.
- Testing revealed that the synthesized mixtures of alkylphosphine sulfides and oxides effectively extract heavy metals like Ni, Co, Zn, Pb, and noble metals such as Ag, achieving extraction rates of over 99%.
Mongolia is located at 45° north latitude in the center of the Asian continent, and about 80% of the territory is at 1000 m above sea level. Epidemiologically, multiple sclerosis (MS) has not been investigated in Mongolia, although there have been a few MS case reports. We investigated the characteristics of MS in Mongolia for the first time, focusing on the association between MS-related parameters and depression levels.
View Article and Find Full Text PDFThe transformation of chronic lymphocytic leukemia to an aggressive lymphoma, called Richter transformation, is often accompanied by resistance to chemotherapy and high mortality. Thus, novel therapeutic strategies are required for the successful treatment of these patients. One possibility is cellular immunotherapy with chimeric antigen receptor T cells.
View Article and Find Full Text PDFThe immune modulatory effects of vitamin D and the impact of vitamin D deficiency on various diseases are a subject of current scientific research. However, there are few data directly linking vitamin D to hard endpoints in clinical studies, apart from its well-known effects on bone health. It is therefore of interest, that the effectiveness of the therapeutic antibody rituximab is connected to the vitamin D serum level of patients with B cell lymphomas.
View Article and Find Full Text PDF