Publications by authors named "A M Bayoumy"
The introduction of biological therapies has revolutionized inflammatory bowel disease (IBD) management. A critical consideration in developing these therapies is ensuring adequate drug concentrations at the site of action. While blood-based biomarkers have shown limited utility in optimizing treatment (except for TNF-alpha inhibitors and thiopurines), tissue drug concentrations may offer valuable insights.
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- Autism spectrum disorder (ASD) is a serious neurodevelopmental issue, and this study investigates the effects of administering MSCs-derived exosomes after birth on a rat model of ASD.
- The research involved dividing male rat pups into control, VPA (exposed to a neurotoxin), and VPA treated with exosomes, assessing changes in behavior and cerebellar structure.
- Results showed that VPA groups exhibited increased activity, social impairments, and disrupted cerebellar structure, while those treated with exosomes showed improvements in histological integrity and behaviors, supported by changes in specific signaling pathways.
Objectives: Vitamin B12 (Cobalamin or Cbl) plays a crucial role in normal human growth and development, as well as in neurological, cardiovascular, and immune systems. Previous studies reported association of high levels of cobalamin with solid cancers, hematological disorders, and liver diseases. Reporting the frequency of comorbid diseases with high serum Vitamin B12 level in patients attending KSAMC at Madinah.
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- The study evaluated the reliability and effectiveness of the Swimmer Arm-to-Shoulder (SAS) test to differentiate between shoulder impingement and cervical radiculopathy in patients with shoulder pain lasting up to 12 weeks.
- In a sample of 718 patients, the SAS test showed high accuracy, with a sensitivity of 89.2% and specificity of 96.1%, effectively identifying the underlying causes of shoulder pain.
- The results concluded that the SAS test is a simple, dependable tool for both screening and confirming diagnoses related to shoulder and cervical spine conditions.