GP emigration from Ireland: an analysis of data from key destination countries.

Background: Ireland is experiencing a general practitioner (GP) workforce crisis, facing an ageing workforce, a growing population with increased life expectancy, and increased complexity of patients. The GP crisis threatens access to primary care in Ireland, as well as Ireland's aim to transform into a primary-care centred system of universal healthcare via the proposed "Sláintecare" healthcare reforms. The challenges faced are common to many countries as health systems seek to expand their medical workforce post-pandemic.

Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer.

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Despite advances in diagnosis and treatment, including surgery, chemotherapy, and immunotherapy, accurate clinical markers are still lacking. The development of prognostic and predictive indicators, particularly in the context of personalized medicine, could significantly improve CRC patient management.

Difficult Intubation Alert Is Associated With a Reduced Incidence of Difficult Intubation.

Introduction: Difficult or failed intubation significantly increases the risk of morbidity and mortality. Documentation of a prior difficult or failed tracheal intubation is a strong predictor of future difficult intubation.

Methods: We undertook a quality improvement project to create a redesigned difficult intubation alert with increased visibility in our electronic health record.

Executive Functioning and Processing Speed as Predictors of Global Cognitive Decline in Alzheimer Disease.

Introduction: There is a lack of cognitive tools to predict disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods: We assessed patients with MCI, AD, and cognitively healthy controls (cHC) using NIH toolbox assessments for attention/concentration and executive functioning and overall cognitive decline by the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog).

Results: Among 183 participants over a median follow-up of 540 days, both between- and within-subjects variance in NIH toolbox and ADAS-Cog assessments increased from cHC to MCI to AD patients.

Flagellum Pumping Efficiency in Shear-Thinning Viscoelastic Fluids.

Microorganism motility often takes place within complex, viscoelastic fluid environments, e.g., sperm in cervicovaginal mucus and bacteria in biofilms.