Publications by authors named "A M Barreca"
Article Synopsis
- The "Galileo" is an AI tool that helps doctors understand kidney biopsy results better and faster before a transplant.
- It was trained using images of kidney biopsies to recognize important things, like normal and damaged parts of the kidney.
- Galileo works much quicker than human doctors, taking only 2 minutes to analyze samples compared to around 25-31 minutes for doctors, which can help improve kidney transplant success.
The recurrence of primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation is associated with a high graft loss rate with standard treatments based on plasmapheresis with/without rituximab. We present 2 consecutive cases of nongenetic early severe recurrent FSGS refractory to rituximab and anti-interleukin 1 treatment and with a partial response to plasmapheresis. Case 1 was a 22-year-old man who was rescue-treated for recurrence 36 weeks after transplantation with obinutuzumab (1000 mg/1.
View Article and Find Full Text PDFBackground: Transplant glomerulopathy (TG) is the hallmark of chronic antibody-mediated rejection but often occurs without anti-HLA donor-specific antibodies (DSAs) in the assumption that other DSAs may be the effectors of the tissue injury. Recently, we reported a positive effect of interleukin-6 (IL-6) receptor blocker tocilizumab (TCZ) in TG/DSA. In the present study, we investigate the effect of TCZ in a cohort of TG cases without detectable anti-HLA DSAs.
View Article and Find Full Text PDFArticle Synopsis
- Kidneys can get affected by conditions called systemic vasculitis, which can show early signs of bigger health problems.
- A special test called renal biopsy is really important for doctors to understand what kind of kidney disease a person has by looking at it under different types of microscopes.
- The review talks about the challenges in recognizing kidney diseases and how new technology like digital tools and AI might help doctors make better and faster decisions.