Bat genomes illuminate adaptations to viral tolerance and disease resistance.

Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order. Infections in bats are largely asymptomatic, indicating limited tissue-damaging inflammation and immunopathology.

Recommendations for improving accessibility of digital health interventions for cardiometabolic disease for ethnically diverse populations.

Digital health interventions (DHIs), such as apps, websites and wearables, are being presented as solutions or enablers to manage the burden of cardiometabolic disease in healthcare. However, the potential benefits of DHIs may not be reaching the most in-need populations, who may face intersecting barriers to accessing health services and digital solutions. The Digital Interventions for South Asians in Cardiometabolic Disease (DISC) study used a mixed-method approach to focus on people of a South Asian background, a high-risk group for cardiometabolic disease.

Mitochondria-targeting nanostructures from enzymatically degradable fluorescent amphiphilic polyesters.

Water-soluble π-conjugated luminescent bioprobes have been broadly used in biomedical research but are limited by the nonbiodegradability associated with their rigid C-C backbones. In the present work, we introduced three naphthalene monoimide (NMI)-functionalized amphiphilic fluorescent polyesters (P1, P2, and P3) prepared by transesterification of functional diols with an activated diester monomer of adipic acid. These polyesters featured a side-chain NMI fluorophore, imparting the required hydrophobicity for self-assembly in water and endowing the polymeric nanoassemblies with green fluorescence.

Local Structure Distortion in Mn, Zn Doped Cu₂V₂O₇: Supercapacitor Performance and Emergent Spin-Phonon Coupling.

Supercapacitors are rapidly gaining attention as next-generation energy storage devices due to their superior power and energy densities. This study pioneers the investigation of Mn/Zn co-doping in α-Cu₂V₂O₇ (CVO) to enhance its performance as a supercapacitor electrode material. Structural and local Structural properties of Mn/Zn co-doped CVO have been investigated through X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), and X-ray Absorption Spectroscopy (XAS), revealing significant distortions that enhance supercapacitor performance.

Ultra-processed food consumption and risk of dementia and Alzheimer's disease: The Framingham Heart Study.

Background: Ultra-processed food consumption is emerging as a risk factor for various cardiometabolic diseases, however its association with dementia and Alzheimer's disease has rarely been explored.

Objectives: We sought to examine whether ultra-processed food consumption is associated with risk of all-cause dementia and Alzheimer's disease among middle-age and older adults.

Design: A prospective cohort study.