Publications by authors named "A M Bajo"
Background/objectives: Prostate cancer (PCa) is characterised by its progression to a metastatic and castration-resistant phase. Prostate tumour cells release small extracellular vesicles or exosomes which are taken up by target cells and can potentially facilitate tumour growth and metastasis. The present work studies the effect of exosomes from cell lines that are representative of the different stages of the disease on the tumoral phenotype of PC3 cells.
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- In the late 1960s and early 1970s, researchers isolated and studied hypothalamic regulatory hormones, discovering both normal and tumor tissues can produce growth hormone-releasing hormone (GHRH).
- GHRH receptors, particularly the pituitary-type (pGHRH-R), are predominantly found in the anterior pituitary but also in other body cells and various cancers, including prostate cancer, with splice variants detected in these tissues.
- GHRH activates multiple signaling pathways that promote cell survival and proliferation, making GHRH receptors potential drug targets, especially in prostate conditions, with recent antagonists showing enhanced anticancer and anti-inflammatory effects.
Article Synopsis
- The study investigates the combined effects of GHRH-R antagonist MIA-690 and EGFR inhibitor Gefitinib on advanced prostate cancer cells, as treating castration-resistant prostate cancer (CRPC) is challenging due to drug resistance.
- Findings show that this combination therapy significantly reduces cell viability, adhesion, and metalloprotease activity, while also causing cell cycle arrest in prostate cancer PC-3 cells.
- In vivo results from athymic nude mice confirm that the combined treatment is more effective against tumors than using either drug alone, by disrupting the interaction between GHRH-R and EGFR pathways.
Prostate cancer (PCa) is the second most frequent and sixth most fatal cancer in men worldwide. Despite its high prevalence, our understanding of its etiology and the molecular mechanisms involved in the progression of the disease is substantially limited. In recent years, the potential participation of exosomes in this process has been suggested.
View Article and Find Full Text PDFNovel water-soluble half-sandwich ruthenium(II) polypyridyl-glycoconjugates [Ru(p-cymene)Cl{N-(1,10-phenanthroline-5-yl)-β-glycopyranosylamine}][Cl] (glycopyranosyl = d-glucopyranosyl (1), D-mannopyranosyl (2), L-rhamnopyranosyl (3) and l-xylopyranosyl (4)) have been synthesized and fully characterized. Their behaviour in water under physiological conditions has been studied by nuclear magnetic resonance spectroscopy, revealing their hydrolytic stability. Interactions of the novel compounds with duplex-deoxiribonucleic acid (dsDNA) were investigated by different techniques and the results indicate that, under physiological pH and saline conditions, the metal glycoconjugates bind DNA in the minor groove and/or through external, electrostatic interactions, and by a non-classical, partial intercalation mechanism in non-saline phosphate buffered solution.
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