A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition.

Background: Transposable elements are ubiquitous and play a fundamental role in shaping genomes during evolution. Since excessive transposition can be mutagenic, mechanisms exist in the cells to keep these mobile elements under control. Although many cellular factors regulating the mobility of the retrovirus-like transposon Ty1 in Saccharomyces cerevisiae have been identified in genetic screens, only very few of them interact physically with Ty1 integrase (IN).

Genome-Wide Mapping of Yeast Retrotransposon Integration Target Sites.

Transposable elements (TEs) are present in virtually all organisms. TE integration into genomes contributes to their structure and evolution, but can also be harmful in some cases. Deciphering where and how TE integration is targeted is fundamental to understand their intricate relationship with their host and explore the outcome of TE mobility on genome evolution and cell fitness.

[Polysomnographic results of surgical treatment of obstructive apnea syndrome].

The study was made of 20 patients suffering from mild, moderate and severe snore and obstructive sleep apnea. The patients were treated surgically but because their upper respiratory pathology varied the intervention consisted of several one-stage operations in the nasal cavity, nasopharynx and oropharynx. To remove nasal obstruction, operations on the nasal septum and/or turbinated bones were made.