Publications by authors named "A M BALANDINA"
Poly(ADP-ribose) polymerase (PARP) inhibitors have been proposed as pharmacological agents in the treatment of various diseases. Recently, factors and mechanisms responsible for regulating PARP catalytic activity have been identified, some of which can significantly influence the effectiveness of inhibitors of this enzyme. In this regard, it is important to develop new models and methods that would reflect the cellular context in which PARP functions.
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- Umbilical cord blood's use in hemostasis testing for newborns is under-researched, leading to this study aimed at evaluating its applicability compared to venous blood samples.
- The study involved 187 newborns and found that umbilical cord blood exhibited a hypocoagulable shift in clotting times and fibrinogen levels, while thromboelastometry and thrombodynamics showed a hypercoagulable shift in newborn blood.
- The differences in hemostatic parameters highlight that newborns have distinct coagulation profiles compared to adults, with implications for understanding their physiological and pathological hemostatic features.
Activated platelets provide phospholipid surface and secrete coagulation factors, enhancing blood clotting. We investigated the role of platelets in the regulation of blood coagulation spatial dynamics. We activated blood clotting with tissue factor-bearing (TF) surface in platelet-rich plasma (PRP) or platelet-free plasma (PFP).
View Article and Find Full Text PDFEvaluation of multiple reaction monitoring cubed performed by a quadrupole-linear ion trap mass spectrometer for quantitative determination of 6-sulfatoxymelatonin in urine.
J Chromatogr B Analyt Technol Biomed Life Sci
February 2022
Liquid chromatography (LC) - mass spectrometry quantitative analysis of substances in biological samples is usually performed in the multiple reaction monitoring (MRM) variant. In complex biological matrices, strong interferences can be observed when using the LC-MRM method. Interference levels can be significantly reduced by using LC - multiple reaction monitoring cubed (MRM).
View Article and Find Full Text PDFBackground: Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess the coagulation and platelet state in IE implementing a wide range of standard and global laboratory assays. We also aim to determine whether prothrombotic genetic polymorphisms play any role in embolization and mortality in IE patients.
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