Publications by authors named "A M Ayral"
Article Synopsis
- The synapse is critical for neuronal communication and is impacted early in neurodegenerative diseases, making it essential to study synapse loss.
- A new high-content screening (HCS) model was developed to quantitatively analyze how gene silencing affects synaptic density using primary neuronal cultures from neonatal rat hippocampus.
- The study details various protocols for culturing neurons, transducing lentiviral shRNAs, immunostaining, image acquisition, and analyzing synaptic density in a streamlined, automated 384-well plate format.
Hereditary hearing loss (HL) is a genetically heterogeneous disorder affecting people worldwide. The implementation of advanced sequencing technologies has significantly contributed to the identification of novel genes involved in HL. In this study, probands of two Turkish families with non-syndromic moderate HL were subjected to exome sequencing.
View Article and Find Full Text PDFPhotocatalytically active silicon carbide (SiC)-based mesoporous layers (pore sizes between 5 and 30 nm) were synthesized from preceramic polymers (polymer-derived ceramic route) on the surface and inside the pores of conventional macroporous α-alumina supports. The hybrid membrane system obtained, coupling the separation and photocatalytical properties of SiC thin films, was characterized by different static and dynamic techniques, including gas and liquid permeation measurements. The photocatalytic activity was evaluated by considering the degradation efficiency of a model organic pollutant (methylene blue, MB) under UV light irradiation in both diffusion and permeation modes using SiC-coated macroporous supports.
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- Hearing loss (HL) is a common condition linked to over 200 different genes, prompting researchers to use exome and genome sequencing to find genetic causes in 322 families from Asia and Latin America.
- The study found that variants in the GJB2 gene were present in 58 participants, but these were excluded from further analysis, as were 38 families with syndromic findings, leading to a focus on 212 families for further genetic testing.
- Exome sequencing revealed 78 variants related to HL in 71 families, with a combined detection rate of 40% using both exome and genome sequencing, the latter proving effective in identifying difficult-to-detect variants in specific genetic regions.
The investigations on the removal of ibuprofen (IBU) in a hybrid system coupling ozonation and nanofiltration with functionalized catalytic ceramic membrane are presented. The gaseous ozone into feed water in concentration of 11 g Nm was supplied. Positive influence of catalytic ozonation on ibuprofen decomposition was observed.
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