Publications by authors named "A M Avellino"
Article Synopsis
- High levels of tumor-associated macrophages (TAMs) in breast cancer are linked to worse outcomes for patients, with lipid buildup in these cells driving tumor growth and spread.
- Recent research reveals that unsaturated fatty acids (like linoleic acid) are more effective than saturated fats at creating lipid droplets in macrophages, using the FABP4/CEBPα pathway to promote this process.
- FABP4 not only aids in lipid metabolism in TAMs but also enhances fat breakdown and utilization in breast cancer cells, fostering cell migration and metastasis, highlighting its critical role in cancer progression.
Objective: The goal of this study was to survey the members of the American Society of Pediatric Neurosurgeons (ASPN) to assess the prevalence and associated risks of burnout among pediatric neurosurgeons. The authors aimed to identify the factors that most significantly contributed to this risk to provide a baseline group of characteristics to improve physician well-being.
Methods: Institutional Review Board approval from the University of Arizona was obtained, and the 7-question and 9-question Mayo Physician Well-Being Index (WBI) was distributed to members of the ASPN (n = 275).
Objective: Intraventricular hemorrhage (IVH) and germinal matrix hemorrhage (GMH) are the most common brain injuries in preterm infants. Neonates with these injuries are at greater risk of impaired neurodevelopmental outcome. Current guidelines recommend screening infants with cranial ultrasound (CUS); however, this is prone to missing subtle injury patterns, particularly within the posterior fossa.
View Article and Find Full Text PDFUnlabelled: A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- * The text outlines a protocol for creating a mouse model of psoriasis using imiquimod and for preparing single-cell suspensions from the skin's epidermal and dermal layers.
- * It also describes methods for detecting FABP5 expression in skin keratinocytes and immune cells through intracellular flow cytometry staining, with detailed guidance referenced in the work of Hao et al. *.