Publications by authors named "A M Atz"
Background: Despite a rigorous screening process, including cardiac catheterization, a subset of patients with a single right ventricle (SRV) demonstrates suboptimal short-term outcomes after the Fontan operation. The goal of this study was to perform a comprehensive assessment of diastolic function in pre-Fontan patients with an SRV using invasive reference-standard measures and determine their associations with post-Fontan outcomes.
Methods And Results: Children aged 2 to 6 years with SRV physiology undergoing pre-Fontan heart catheterization were recruited prospectively.
Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.
Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative.
Objective: In the SVR trial (Single Ventricle Reconstruction), newborns with hypoplastic left heart syndrome were randomly assigned to receive a modified Blalock-Taussig-Thomas shunt (mBTTS) or a right ventricle-to-pulmonary artery shunt (RVPAS) at Norwood operation. Transplant-free survival was superior in the RVPAS group at 1 year, but no longer differed by treatment group at 6 years; both treatment groups had accumulated important morbidities. In the third follow-up of this cohort (SVRIII [Long-Term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type]), we measured longitudinal outcomes and their risk factors through 12 years of age.
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- - The RECOVER-Pediatrics study aims to investigate the prevalence and long-term effects of Long COVID (PASC) in children and young adults, addressing the need for more research in this area.
- - The study recruits caregiver-child pairs and young adults across 100+ sites in the U.S., focusing on a diverse group of participants with and without prior SARS-CoV-2 infections, and will collect data over several years through various tiers of assessments.
- - The ultimate goal of the study is to understand the clinical trajectory, mechanisms, and sociodemographic factors related to pediatric PASC, thereby contributing to potential treatments and public health responses.
Article Synopsis
- * The SVRIII Brain Connectome study aims to analyze neuroimaging from patients and healthy controls but has faced recruitment and logistical challenges, especially during the COVID-19 pandemic.
- * Solutions included adding more study sites, improving coordination among researchers, and implementing new strategies for recruiting healthy controls while also overcoming technical issues with neuroimage collection.