Genome Studies in L. and L. Based on Repeatomic and Cytogenetic Data.

L. and L. are valuable and promising food crops for multi-purpose use that are distributed worldwide in temperate, subtropical, and tropical zones.

[Analysis of the work of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023].

The article demonstrates a detailed analysis of the results of the rounds of quality control of immunohistochemical studies conducted by the Central Committee of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023. Typical shortcomings and errors in the immunohistochemical examination of various tumors have been identified and ways to eliminate them are given. Particular attention is paid to defining a panel of standard breast cancer markers and eliminating the shortcomings of immunohistochemical examination of markers of accompanying diagnosis.

[Tumor infiltrating lymphocytes (TILs) in triple negative breast cancer].

Background: Tumor infiltrating lymphocytes (TILs) are a promising inexpensive prognostic and predictive biomarker in breast cancer. High levels of TILs are associated with improved survival and higher probability to achieve pathological complete response in triple-negative breast cancer (TNBC).

Objective: To assess the level of TILs in TNBC samples and analyze the association between the level of TILs and the main pathological parameters, to identify their impact on long-term results.

Eco-Geographical and Botanical Patterns of Resistance to Lepidoptera Insects in L.

In the context of the widespread expansion of damage by herbivorous pests of crops, taking into account the requirements for minimizing pesticide pollution of the environment, it is important to have fundamental knowledge of the geographical features of the distribution of pests and about the botanical confinement of plant resistance in order to develop a strategy for creating new cultivars with complex resistance to insects. The relevance of our work is related to the study of the variability in the degree of resistance of the extensive genetic diversity of accessions to the main herbivorous pests of crops in contrasting ecological and geographical zones of the Russian Federation (Arctic, northwestern, and southern zones). We have studied the distribution and food preferences of Lepidoptera insects (diamondback moth and cabbage moth ) on a set of 100 accessions from the VIR collection (Chinese cabbage, pakchoi, wutacai, zicaitai, mizuna, and leaf and root turnips) in the field in three zones of the Russian Federation.

Resistance of breast cancer cells to paclitaxel is associated with low expressions of miRNA-186 and miRNA-7.

Neo-adjuvant chemotherapy is a common approach for the complex treatment of breast cancer (BC) and paclitaxel (PTX) is frequently included in the therapeutic regimen. However, the effect of PTX-based treatment is hard to predict precisely based on routinely used markers. As microRNAs are considered a new promising class of biomarkers, the link between miRNA expression and PTX resistance of BC cells needs to be well investigated.