Publications by authors named "A M Amedee"
Article Synopsis
- People with existing health issues, like metabolic problems, face higher risks for severe complications from SARS-CoV-2, and a high fat, high sugar diet (HFSD) and alcohol use may raise virus entry-related factors in cells.
- A study on SIV-infected macaques found that those on an HFSD had significantly higher levels of the ACE2 receptor in lung and pancreatic tissues compared to those on a standard diet, while alcohol consumption did not affect these levels.
- The findings suggest that a poor diet might heighten the risk for infections like COVID-19 by increasing key receptor expressions, highlighting the link between diet quality and virus susceptibility.
Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain. Previously, we demonstrated that colony-stimulating factor 1 receptor (CSF1R) in PVMs was upregulated and activated in chronically SIV-infected rhesus macaques with encephalitis, correlating with SIV infection of PVMs. Herein, we investigated the role of CSF1R in the brain during acute SIV infection using BLZ945, a brain-penetrant CSF1R kinase inhibitor.
View Article and Find Full Text PDFSafety of Cryoneurolysis as a Preoperative Treatment for Total Knee Arthroplasty (TKA).
Surg Technol Int
September 2023
Cryoneurolysis is a minimally invasive procedure that utilizes extreme cold temperature to achieve thermal neurolysis of peripheral sensory nerves. This study aimed to evaluate the safety of cryoneurolysis as a preoperative treatment for total knee arthroplasty (TKA) and assess the incidence of major and minor wound complications associated with the procedure. A retrospective chart review was conducted on 357 patients who underwent cryoanalgesia within two weeks of their scheduled TKA.
View Article and Find Full Text PDFArticle Synopsis
- Effective antiretroviral therapy has made HIV a manageable chronic disease, particularly impacting those over 50, with HIV targeting specific immune cells (CD4 T cells) that express co-receptors CCR5 and CXCR4.
- Research on male rhesus macaques shows that chronic binge alcohol consumption increases the percentage of gut CD4 T cells expressing the co-receptor CXCR4 and that hormone loss may raise levels of activated T cells.
- The study found that combining chronic binge alcohol and ovariectomy in SIV-infected female macaques resulted in higher levels of activated CD4 T cells and disrupted mitochondrial homeostasis, offering insights into alcohol's effects on viral expression in these cells.
Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques.
Am J Physiol Regul Integr Comp Physiol
November 2021
Article Synopsis
- Aging individuals with HIV, particularly postmenopausal women, face a greater risk of health issues linked to their condition and lifestyle factors like alcohol consumption.
- Research in SIV-infected female macaques showed that chronic binge alcohol intake negatively impacted glucose-insulin response and pancreatic function, while the removal of ovaries (OVX) also affected pancreatic health but didn’t change glucose response significantly.
- The study indicates that both chronic alcohol use and ovarian hormone loss can worsen metabolic dysfunction in those with HIV, highlighting a vulnerability that could affect treatment and health management.