Integration of RNA Editing with Multiomics Data Improves Machine Learning Models for Predicting Drug Responses in Breast Cancer Patients.

The integration of conventional omics data such as genomics and transcriptomics data into artificial intelligence models has advanced significantly in recent years; however, their low applicability in clinical contexts, due to the high complexity of models, has been limited in their direct use inpatients. We integrated classic omics, including DNA mutation and RNA gene expression, added a novel focus on promising omics methods based on A>I(G) RNA editing, and developed a drug response prediction model. We analyzed 104 patients from the Breast Cancer Genome-Guided Therapy Study (NCT02022202).

Validation of an infectious bronchitis virus GVIII-specific RT-PCR assay and first detection of IB80-like strains (lineage GVIII-2) in Italy.

Infectious bronchitis virus (IBV) is a pathogen causing respiratory, renal and reproductive clinical forms in chickens of all ages and productive categories. Its proneness to mutation and recombination gave rise to a plethora of variants differing in terms of pathogenicity, antigenicity, and distribution, with relevant implications for disease control, mainly pursued by routine vaccination, and diagnosis, requiring a steady update of molecular and serological methods. Among the most recent additions to the current phylogenetic classification, based on S1 gene sequencing, is the discovery of an eighth genotype (GVIII), further divided into lineages GVIII-1 and GVIII-2.

Characterisation and Profiling of Standard Atopic Dermatitis Therapies in a Chronic Dermatitis Murine Model Induced by Oxazolone.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by hypersensitivity to allergens, eczematous lesions and pruritus. The aim of this study was to comprehensively characterise a murine model of dermatitis and assess the similarity with the human disease, as well as to profile clinically relevant AD therapies. Four repeated topical administrations of oxazolone in the auricular skin of sensitised mice induced morphological features compatible with AD, including redness and swelling, as well as histological changes typical of spongiotic (eczematous) dermatitis and increased plasmatic IgE.

Selective recovery of Co(II), Mn(II), Cu(II), and Ni(II) by multiple step batch treatments with nanocellulose products.

The recovery of Co(II), Mn(II), Ni(II), and Cu(II) from black mass e-waste solutions through cellulose nanofibers (CNFs) and nanocrystals (CNCs) was investigated. These materials were synthetized by TEMPO-oxidation followed by high-pressure homogenization, and acid hydrolysis, respectively. The NC characterization included the measurement of consistency, cationic demand, carboxylic content, dissolved amorphous cellulose, and transmittance at λ = 600 nm.

Immunometabolic effects of -carotene and vitamin A in atherogenesis.

Carotenoids are a diverse group of lipids produced by photosynthetic organisms, and therefore, these compounds are major components of healthy diets. Carotenoids are among the most extensively studied micronutrients to date due to their antioxidant and provitamin A properties. -carotene is one of the most abundant carotenoids in our diet, but more importantly, it is the main vitamin A precursor in humans.