Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients.

Background And Objective: Vancomycin is commonly prescribed in treatment of methicillin-resistant Staphylococcus aureus infections. While, vancomycins' pharmacokinetic vary among older patients, there is a paucity of data regarding specific characteristics influencing pharmacokinetics in Saudi adult patients. This study aims to establish a population-pharmacokinetic (Pop-PK) model for vancomycin in patients admitted to medical wards, with the focus on identification of patient characteristics influencing vancomycin trough concentrations.

Awareness, Knowledge, Attitudes, and Practices of Diabetic Nephropathy Among the General Population in Hafr Al Batin, Saudi Arabia: A Cross-Sectional Study.

Background Diabetic nephropathy, a leading cause of end-stage renal disease (ESRD), plays a part in the critical healthcare burden globally, especially in Saudi Arabia, where the prevalence of diabetes cases is among the highest worldwide. This study aims to assess the awareness, knowledge, attitudes, and practices (A-KAP) in relation to diabetic nephropathy among the general population in Hafr Al Batin, Saudi Arabia. Methods A cross-sectional study was conducted between January and September 2024, involving 406 participants with a minimum age range of 18 years and older.

The prevalence of polypharmacy and hyper-polypharmacy among middle-aged vs older patients in Saudi Arabia: a cross-sectional study.

Introduction: Polypharmacy, the use of multiple medications, is a growing concern among middle-aged and older patients, posing potential risks and challenges in healthcare management.

Aim: This study aimed to identify the prevalence of polypharmacy and hyper-polypharmacy among populations of middle-aged vs older patients and identify its associated common comorbidities and prescribed medications in Qatif Central Hospital (QCH), Saudi Arabia.

Methods: Patients aged 40 years or older who presented to an outpatient medical care clinic at QCH, Saudi Arabia, between 1 January and 31 December 2021 were included, and their comorbidities, prescribed medications, and recent clinical laboratory test results were collected.

Safety and Efficacy of Direct Oral Anticoagulant in Addition to Antiplatelet Therapy After Acute Coronary Syndrome: A Systemic Review and Meta-analysis of 53,869 Patients.

Introduction: Significant progress has been made in the management of patients with acute coronary syndrome (ACS) during the past few decades. However, the role of direct oral anticoagulants (DOACs) in post-ACS prophylactic therapy remains unknown. This study aims to assess the efficacy and safety of DOACs plus antiplatelet treatment (APT) after ACS.