[Lipid peroxidation in patients with hypertension and renal hypertension against a background of diabetes mellitus].

Time course of changes was studied in parameters characterizing lipid peroxidation (LPO) and the total lipids counts in red cell membranes (RCM) and blood plasma (BP) of patients with hypertensive disease (HD) and arterial hypertension in chronic pyelonephritis against the background of diabetes mellitus (DM). The study groups were DM patients (group I), those with coexistent HDDM (group II), and those with arterial hypertension caused by chronic pyelonephritis in the presence of DM (group III). All three groups of patients demonstrated intensification of the cellular membrane- and blood plasma LPO as well as increase in the total lipids counts.

[The comparative evaluation of the efficacy of tocopherol acetate in the combined treatment of patients with hypertension and diabetes mellitus].

Time course was studied of indices for lipid peroxidation (LPO) and total lipids count in erythrocytic membranes (EM) and blood plasma (BP) of patients with essential hypertension (EH) associated with diabetes mellitus (DM), under the effect of alpha-tocopherol. EH patients demonstrated intensification of LPO in cellular membranes and BP. Association of EH with DM is responsible for a more significant increase of the levels of accumulation of LPO products in EM and rise in total lipids content both in cellular membranes and BP.

[The use of antioxidants (alpha-tocopherol acetate) in the treatment of diabetes mellitus].

The authors have examined the time course of lipid peroxidation processes and the levels of total lipids in red cell membranes and blood plasma of diabetics administered alpha-tocopherol acetate. Patients with medium-severe diabetes of the first and second types were divided into 2 groups. Group 1 patients were administered only traditional sugar-reducing treatment, in Group 2 alpha-tocopherol acetate in a daily dose 300 mg was added to such therapy.