Publications by authors named "A M Aboulenein"
Background: Atypical hemolytic uremic syndrome (aHUS) is an important cause of acute kidney injury in children. It is primarily caused by dysregulation of the complement alternative pathway due to genetic mutations, mainly in complement factor H genes, or due to anti-factor H autoantibodies (anti-FH), leading to uncontrolled overactivation of the complement system. Early diagnosis and treatment of autoimmune HUS (AI-HUS) is essential and leads to a favorable outcome.
View Article and Find Full Text PDFBackground And Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits , including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against Ehrlich ascites carcinoma (EAC) in female Swiss albino mice.
View Article and Find Full Text PDFArticle Synopsis
- Organic extracts from willow leaves showed anticancer effects against breast, colorectal, cervical, and liver cancer cell lines, with specific activities linked to chloroform and ethyl acetate fractions.
- These extracts caused cancer cell death through apoptosis, while minimally affecting non-cancerous cells, indicating a targeted therapeutic potential.
- Additionally, the extracts enhanced pro-apoptotic protein levels and reduced anti-apoptotic markers, emphasizing the significant role of phenolic and flavonoid compounds as antioxidants and anticancer agents.
Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps).
View Article and Find Full Text PDFBackground And Objective: Egypt produced 236,314 t of artichoke in 2016, which produce a huge amount of useless by-product, which can be used as cheaper source for many active compounds can be applied for some medical application. The objective of this study was to assess the toxicity of the artichoke by-product extract through its effect on rats' kidney, brain and liver biomarkers.
Materials And Methods: Chemical composition of artichoke by-product (crude protein, crude fiber, crude fat and minerals) was determined.