Cytotoxic evaluation of new polyhydroxylated steroids from the Red Sea soft coral (Macfadyen, 1936).

An efficient column chromatography of the CHCl/MeOH crude extract from the soft coral (Macfadyen, 1936) yielded seven steroids, including five 4α-methylated steroids () and two 19-oxygenated steroids (). Notably, both compounds and are new, identified as (22)-4α,24-dimethyl-5α-cholesta-22,24(28)-dien-3β,8β-diol () and (22,24)-7β-acetoxy-24-methyl-cholesta-5,22-dien-3β,19-diol (). The chemical structures and relative configurations were elucidated through comprehensive spectroscopic analyses, including 1D and 2D NMR, as well as HRESIMS analysis.

New Cytotoxic Monoalkyl Glycerol Ether from the Red Sea Soft Coral Nephthea mollis.

A new monoalkyl glycerol ether, 3-(n-henicosyloxy)propane-1,2-diol (1), was isolated from the CH Cl /MeOH crude extract of the Red Sea soft coral Nephthea mollis. Additionally, three known related analogs were identified: chimyl alcohol (2), batyl alcohol (3), and 3-(icosyloxy)propane-1,2-diol (4). The chemical structure of 3-(n-henicosyloxy)propane-1,2-diol was determined using advanced spectroscopic analyses, including 1D, 2D Nuclear Magnetic Resonance (NMR), Electron Ionization mass spectra (EI-MS), and High-Resolution Electron Spray Ionization mass spectra (HR-ESI-MS) analyses.

Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral .

A successful column chromatography of a CHCl/MeOH crude extract of soft coral led to the isolation of two new aromatic A-ring steroids (), together with three known compounds (). Both and are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses.

Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from , a Red Sea Soft Coral.

Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. (Alcyoniidae) a Red Sea-derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F () and G (), as well as four identified analogues (-) together with a furan derivate () were isolated from a solvent extract.