Publications by authors named "A Luetkemeyer"

Article Synopsis
  • The rising rates of sexually transmitted infections (STIs) have heightened health concerns, prompting research into doxycycline postexposure prophylaxis (doxyPEP) as a preventive strategy for bacterial STIs.
  • A study was conducted in San Francisco to evaluate how the introduction of doxyPEP guidelines affected reported cases of chlamydia, gonorrhea, and early syphilis among men who have sex with men (MSM) and transgender women.
  • Results revealed a significant decrease in STI cases among these populations after the implementation of doxyPEP guidelines, with chlamydia and early syphilis cases declining by 6.58% and 2.68% per month, respectively, compared to
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Background: Doxycycline post-exposure prophylaxis (doxy-PEP) reduces chlamydia, gonorrhea, and syphilis infections among men who have sex with men (MSM) and transwomen (TW). Perspectives of health care providers (HCPs) regarding doxy-PEP can inform implementation efforts.

Methods: From August 2022 to January 2023, HCPs were recruited from 13 cities with high sexually transmitted infection (STI) rates for semi-structured, in-depth interviews about their awareness of and attitudes towards doxy-PEP for STI prevention.

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Doxycycline post-exposure prophylaxis (doxy-PEP) reduces the risk of bacterial sexually transmitted infections (STIs) among men who have sex with men and transgender women. In the United States, doxy-PEP is in an early stage of integration into clinical practice, and national guidelines for its use were recently released. The goal of this manuscript is to provide practical guidance for clinicians who are considering or currently prescribing doxy-PEP.

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Article Synopsis
  • Doxycycline post-exposure prophylaxis (doxy-PEP) is effective in reducing bacterial sexually transmitted infections among men who have sex with men and transgender women but raises concerns about its impact on antimicrobial resistance.
  • A study involving participants from the DoxyPEP trial assessed the effects of doxy-PEP on the gut microbiome and antimicrobial resistance genes by comparing metagenomic and metatranscriptomic data over six months between those receiving doxy-PEP and standard care.
  • Results showed an increase in tetracycline resistance genes among participants using doxy-PEP, with a significant enrichment of these genes correlated with the number of doxycycline doses taken.
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Article Synopsis
  • - The study assessed the effectiveness of a COVID-19 Sanofi booster vaccine by measuring neutralizing antibody levels in COVAIL recipients as a predictor of COVID-19 risk.
  • - Higher levels of antibody titers were found to be associated with a lower risk of COVID-19, indicated by adjusted hazard ratios of 0.30 and 0.25 for different titer measurements.
  • - An increase of 10-fold in the weighted average titer substantially reduced the risk, suggesting that higher antibody levels can offer better protection against the virus.
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