Publications by authors named "A Lteif"
Our objectives are to report on the outcomes of adrenal insufficiency (AI) and cerebral ALD (cALD) in children diagnosed with X-linked adrenoleukodystrophy (ALD) identified by newborn screening (NBS) in Minnesota in the first 5 years following initiation of NBS in 02/2017. A retrospective chart review was conducted for children diagnosed with ALD via Minnesota NBS from 02/06/2017 through 02/06/2022. Data reviewed included newborn screening data, diagnostic very long chain fatty acid levels, ABCD1 molecular testing results, serial measurements of ACTH and cortisol, and serial brain MRI results.
View Article and Find Full Text PDFUnveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: Insights.
Curr Res Pharmacol Drug Discov
October 2024
Article Synopsis
- The study evaluates two platinum (IV) complexes, P-PENT and P-HEX, for their effectiveness against skin cancer, showing strong cytotoxic effects on HaCaT-II-4 cells while being less harmful to mesenchymal stem cells.
- The complexes trigger intrinsic apoptosis through key biochemical pathways, increasing apoptotic markers and reactive oxygen species, suggesting they induce cancer cell death.
- In a mouse model, both complexes significantly inhibited tumor growth with lower doses than those used for traditional treatments like cisplatin, indicating they might be safer and more effective options for skin cancer therapy.
Background: Overweight and obesity are common in the veteran population. Medical management with semaglutide, orlistat, liraglutide, phentermine, phentermine/topiramate, and naltrexone/bupropion is increasingly common. This study expands on a 2021 study and evaluates medication effectiveness.
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- A study analyzed paired baseline and end-of-treatment circulating tumor DNA (ctDNA) samples from the MONALEESA trials to identify genetic changes in patients with HR+/HER2- advanced breast cancer treated with ribociclib plus endocrine therapy (ET) or a placebo.
- The analysis included 523 samples, revealing 21 genes with significant alterations at end-of-treatment, particularly highlighting increased mutations in RB1 and SPEN in the ribociclib group, while ESR1 mutations were noted in both treatment arms.
- The findings suggest acquired genetic alterations related to treatment response and resistance, providing insights for future research on resistance mechanisms and potential systemic therapies following CDK4/6 inhibitors.
The growing interest in the therapeutic potential of cannabidiol (CBD) has led to the need for effective and reliable delivery methods that overcome its low oral absorption. Zeolites, a class of porous nanoparticles, offer unique advantages as drug carriers due to their high surface area and adjustable pore size. In this study, a zeolite-based drug delivery system was developed for the encapsulation of CBD.
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