Publications by authors named "A Loza-Vazquez"
Objective: Our aim was to analyse the relation between serial values of the indocyanine green plasma disappearance rate (ICG-PDR) with hospital mortality in the first 48 hours of ICU admission in patients with septic shock.
Methods: A prospective observational study was carried out over 12 months of patients admitted to the ICU with septic shock. Each patient underwent noninvasive determination of ICG-PDR at 24 and 48 hours with the LiMON® module.
Background: Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.
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- The study investigates the effectiveness of procalcitonin (PCT) and C-reactive protein (CRP) as biomarkers for identifying bacterial coinfection in COVID-19 patients admitted to ICUs in Spain.
- Of 4,076 patients studied, only 3% had bacterial coinfection, and while PCT and CRP showed high negative predictive values, their overall predictive capability was found to be low.
- The findings indicate that measuring PCT and CRP at hospital admission is not a reliable method for diagnosing bacterial coinfection in COVID-19 pneumonia patients.
Background: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU.
View Article and Find Full Text PDFBackground: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19.
Methods: We did a prospective cohort study across 23 hospitals in Spain.