Publications by authors named "A Louboutin"
Article Synopsis
- * The study reviews six cases of MEN1 mosaicism from the literature alongside six additional cases reported by the French TENgen network.
- * Findings indicate that MEN1 mosaicism has a similar severity as typical MEN1 mutations and calls for better detection methods to enhance patient monitoring and genetic counseling.
Article Synopsis
- Whole-exome sequencing (WES) combined with testicular sperm extraction (TESE) offers valuable insights for men experiencing maturation arrest (MA) after a first unsuccessful TESE.
- Current clinical guidelines lack predictive tests for outcomes in recurrent TESE following MA, and WES could fill this gap, aiding in decision-making.
- The study analyzed 26 men with idiopathic non-obstructive azoospermia and identified various genetic variants that may impact spermatogenesis, suggesting potential pathways for future research and patient management.
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third of ER+ patients. Tumor resistance is still ERα-dependent, but mutations usually confer constitutive activation to the hormone receptor, rendering ERα modulator drugs such as tamoxifen and aromatase inhibitors ineffective. Fulvestrant is a potent selective estrogen receptor degrader (SERD), which degrades the ERα receptor in drug-resistant tumors and has been approved for the treatment of hormone-receptor-positive metastatic breast cancer following antiestrogen therapy.
View Article and Find Full Text PDFPerformance of MRI for the detection of anterior pelvic endometriotic lesions.
J Gynecol Obstet Hum Reprod
December 2018
Objective: To study the performance of MRI for the detection of anterior pelvic endometriotic lesions.
Materials And Methods: We carried out a retrospective, single site, case-controlled study of patients who underwent surgery for endometriosis between March 2005 and December 2013. Laparoscopy was used to obtain the reference diagnosis of the endometriotic lesions.
External validation of the MR imaging scoring system for the management of adnexal masses.
Eur J Obstet Gynecol Reprod Biol
October 2016
Objective: To investigate the prognostic value of ADNEX Magnetic Resonance Imaging Scoring in the preoperative management of adnexal masses.
Study Design: We performed a retrospective study on patients who underwent surgery for an adnexal mass, with prior exploration by Magnetic Resonance Imaging (MRI), at the Gynecology Department of the Poissy Teaching Hospital between May 2012 and August 2014. MRI data were retrospectively read by radiologists, without knowledge of the histology, and classified according to the criteria of the ADNEX MR score.