Publications by authors named "A Loth"

Article Synopsis
  • - Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma, and its subtypes have varying outcomes, prompting efforts to better predict patient prognosis based on cell origin.
  • - This study focused on analyzing the migration abilities of two genetic subtypes of DLBCL, MCD and EZB, using specific tests to measure their movement through microchannels and narrow spaces.
  • - Results showed that EZB-type cells migrated faster and more effectively through constrictions than MCD-type cells, which had higher levels of a protein affecting nuclear stiffness, suggesting that genetic differences may impact both therapy outcomes and tumor cell motility.
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Salivary gland cancer (SGC) is a rare cancer that can present a diagnostic challenge to pathologists, with emerging, but still limited options for the treatment of recurrent/metastatic disease. We aimed to characterize the cohort of salivary gland cancers in our institute and generate a tissue microarray (TMA) with clinical data available for immunohistochemical analysis. We extracted the cases of salivary gland cancers in our institute and generated a TMA with 72 patients between 2002 and 2017 with sufficient paraffin block material.

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Purpose: Clinical registries have great potential for quality control of medical procedures regarding the indications, therapeutic processes and results, including their possible complications. This is particularly true when providing patients with severe hearing loss or deafness with a cochlear implant (CI). This treatment represents a lifelong care process that requires continuous quality control over time.

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Fluorescence confocal microscopy (FCM) is an optical technique that uses laser light sources of different wavelengths to generate real-time images of fresh, unfixed tissue specimens. Unlike conventional histologic evaluation methods, FCM is able to assess fresh tissue samples without the associated cryo artifacts typically observed after frozen sectioning. The purpose of this study was to evaluate the utility of FCM imaging in the differential diagnosis of cervical lymphadenopathy.

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Background: Tinnitus is one of the most common otologic comorbidities, particularly in older patients with severe hearing loss or deafness. Cochlear implants (CI) have been used for hearing rehabilitation more and more successfully in elderly patients and CI treatment is performed in Germany without an age limit. The aim of this follow-up study was to assess the tinnitus burden in the long-term follow-up of elderly patients with hearing rehabilitation using CI.

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