Publications by authors named "A Lorentz"
The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointestinal microbiota and disruption of the biological clock have been implicated and studied as diagnostic and therapeutic targets. Here, we examine the relationship of IBD to biological clock and gut microbiota by using the IL-10 deficient () mouse model for microbiota-dependent spontaneous colitis in combination with altered (4 h/4 h) light/dark cycles to disrupt and time-restricted feeding (TRF) to restore circadian rhythmicity.
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- - Intermittent fasting (IF), particularly alternate day fasting (ADF) and time-restricted eating (TRE), shows promise in reducing intestinal inflammation, with various studies highlighting its potential health benefits.
- - Animal studies demonstrate that IF can improve inflammatory markers, oxidative stress, and gut microbiota composition, indicating a strong anti-inflammatory effect.
- - While studies on humans with inflammatory bowel disease (IBD) are lacking, research on healthy subjects suggests that TRE and ADF may lower inflammation levels and enhance gut health, with outcomes influenced by the duration of fasting periods.
The pandemic of COVID-19 has imposed tremendous pressure on public health systems and social economic ecosystems over the past years. To alleviate its social impact, it is important to proactively track the prevalence of COVID-19 within communities. The traditional way to estimate the disease prevalence is to estimate from reported clinical test data or surveys.
View Article and Find Full Text PDFNeutrophils are sentinel immune cells with essential roles for antimicrobial defense. Most of our knowledge on neutrophil tissue navigation derived from wounding and infection models, whereas allergic conditions remained largely neglected. Here, we analyzed allergen-challenged mouse tissues and discovered that degranulating mast cells (MCs) trap living neutrophils inside them.
View Article and Find Full Text PDFThe pandemic of COVID-19 has imposed tremendous pressure on public health systems and social economic ecosystems over the past years. To alleviate its social impact, it is important to proactively track the prevalence of COVID-19 within communities. The traditional way to estimate the disease prevalence is to estimate from reported clinical test data or surveys.
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