Solid acids as cocatalysts in the chelation-assisted hydroacylation of alkenes and alkynes.

The use of homogeneous Brønsted acid cocatalysts (such as benzoic acid) in hydroacylation reactions imine intermediates has been extensively studied. However, the use of heterogeneous cocatalysts has been limited to montmorillonite K10. Thus, we can use other solid acids to increase the efficiency of the reaction.

Physiotherapy intervention in Smith-Magenis syndrome: A case report based on exercise therapy for postural control and balance.

Key Clinical Message: This case report aims to raise a physiotherapy intervention for subjects with SMS. The basis is an active work, based on postural control and balance training. Physiotherapists can play an important role in the management of these subjects.

Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation.

Introduction: The placenta provides nutrients to the fetus, and it has protective effects against harmful substances. Unhealthy maternal diets and toxic agents might increase free radical (FR) production. Elevated FR levels are associated with a high risk of oxidative stress, which may cause DNA damage.

A novel and easy protocol to obtain 6-alkoxy-Δ-diene-3-one derivatives from available sterols.

Herein we report an unprecedented and efficient methodology for accessing 6-alkoxy-Δ-diene-3-one derivatives. Such scaffolds were serendipitously obtained in the course of the study of the reaction of Δ-3-keto steroids with catalytic amounts of iodine in refluxing methanol. A series of 6-methoxy and 6-ethoxy- Δ-diene-3-ones were prepared from easily-available sterols in a two-step sequence; first, oxidation of sterols furnished the Δ-3-keto steroids, which were then refluxed with ethanol or methanol with I as catalyst to obtain a series of ten derivatives.

The sodium borate relieves the hypertrophic damage induced during pregnancy, it improves contractibility, reduces oxidative stress and stimulates cell proliferation.

Introduction: Fetal and postnatal hypertrophy develop in response to such different exposures or illnesses the mother suffers during gestation as anti-infectious and physical agents, obesity, hypertension, diabetes, and even advanced maternal age. This gives rise to high comorbidities in the newborn; therefore, looking for alternatives that contribute to cardiac homeostasis is quite necessary to inhibit the overgrowth of myocytes. Boron-derivative compounds could play a key role in exerting a repairing effect on chronic cardiac damage induced during gestation.