Publications by authors named "A Lopez-Sebastian"
Herein, we analyzed the in vitro effect induced by total lipid extracts from Trypanosoma cruzi amastigotes of RA and K98 strains, which were obtained after overnight incubation (RAinc and K98inc) to mimic phospholipid hydrolytic processes that occurred adjacent to degenerating amastigote nests in tissues of Chagas disease patients. We demonstrated that RAinc and K98inc might possess bioactive lipid molecules with anti-inflammatory bias since they inactivated the NF-κB pathway, in contrast to intact lipids. Moreover, different M1/M2 macrophage phenotype markers of polarization were analyzed by RT-qPCR which evidenced that RAinc and K98inc promoted an increased expression of the M2 markers Arginase-1, IL-10, FIZZ and YM-1, and a decreased expression of iNOS and proinflammatory cytokines IL-6 and TNF-α.
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- After a blastocyst hatches, ungulate embryos go through a long phase called conceptus elongation, which is a crucial time when embryos can be lost.
- Scientists studied a specific gene called PPARG to see if it is necessary for the development of cattle embryos by creating embryos without this gene and comparing them to normal embryos.
- They found that even without PPARG, the embryos still developed normally through important stages, so PPARG is not essential for their growth.
Article Synopsis
- - This study investigated how changes in prolactin (PRL) levels affect the resistance of sperm from ibex and mouflon to freezing processes, using drugs bromocriptine (BCR) and sulpiride (SLP) to manipulate PRL during different seasons.
- - BCR reduced PRL levels, leading to lower sperm motility in mouflons with slow-freezing and improved motility with ultra-rapid freezing, while SLP increased PRL and resulted in lower sperm viability and integrity in both species.
- - Results indicate that high PRL levels negatively impact sperm quality and cryoresistance, with varying effects on sperm head dimensions between ibex and mouflons.
1. Birchen and Blue Leonesa are two endangered chicken breeds mainly raised in Curueño Valley in North Spain. The establishment of a germplasm bank to guarantee the preservation of these breeds is needed.
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