Publications by authors named "A Lopez de Cerain"
Article Synopsis
- - The comet assay is a flexible method used to identify DNA damage in individual eukaryotic cells, applicable to various species from yeast to humans, detecting issues like DNA strand breaks and other forms of damage.
- - Modifications to the protocol are necessary based on the specimen to minimize additional DNA damage during sample processing and to enhance the detection of damage differences.
- - The method has been validated for various applications in research and has gained recognition as an in vivo genotoxicity test by the OECD, with guidelines provided for its use across different cell types and DNA damage assessments.
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Purpose: The aim of this study was to develop an immunogenic protective product against Shigella flexneri by employing a simple and safe heat treatment-based strategy.
Methodology: The physicochemical characteristics of naturally produced (OMV) and heat-induced (HT) outer-membrane vesicles from S. flexneri were examined, including a comparison of the protein content of the products.