Publications by authors named "A Lopez Leyva"
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses.
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- Defenses against oxidants, particularly superoxide scavenging enzymes (SOSEs), are vital for the survival of pathogens, especially aerobes, but much of the existing knowledge is based on bacteria that have these enzymes.
- This study explores the evolution of a pathogen lacking SOSEs and how it develops alternative mechanisms to handle superoxide stress, showing that despite losing superoxide dismutase (SOD), it can still adapt effectively.
- The research highlights the significance of pathways related to cysteine and leucine biosynthesis in combating superoxide and suggests that cysteine oxidation plays a central role in handling superoxide toxicity, challenging traditional views on how bacteria adapt to oxygen-related stress.
Arsenic poses a global threat to living organisms, compromising crop security and yield. Limited understanding of the transcriptional network integrating arsenic-tolerance mechanisms with plant developmental responses hinders the development of strategies against this toxic metalloid. Here, we conducted a high-throughput yeast one-hybrid assay using as baits the promoter region from the arsenic-inducible genes ARQ1 and ASK18 from Arabidopsis thaliana, coupled with a transcriptomic analysis, to uncover novel transcriptional regulators of the arsenic response.
View Article and Find Full Text PDFBackground: Within-breath analysis of oscillometry parameters is a growing research area since it increases sensitivity and specificity to respiratory pathologies and conditions. However, reference equations for these parameters in White adults are lacking and devices using multiple sinusoids or pseudorandom forcing stimuli have been underrepresented in previous studies deriving reference equations. The current study aimed to establish reference ranges for oscillometry parameters, including also the within-breath ones in White adults using multi-sinusoidal oscillations.
View Article and Find Full Text PDFPhotoaging is the premature aging of the skin caused by prolonged exposure to solar radiation. The visual alterations manifest as wrinkles, reduced skin elasticity, uneven skin tone, as well as other signs that surpass the expected outcomes of natural aging. Beyond these surface changes, there is a complex interplay of molecular alterations, encompassing shifts in cellular function, DNA damage, and protein composition disruptions.
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