Threshold crossing time theory for quasicycles with application to brain rhythms.

The amplitude of a two-dimensional Ornstein-Uhlenbeck colored noise process evolves according to the one-dimensional Rayleigh process. This is a general model for the random amplitude fluctuations of a quasicycle, i.e.

Shortcutting from self-motion signals reveals a cognitive map in mice.

Animals navigate by learning the spatial layout of their environment. We investigated spatial learning of mice in an open maze where food was hidden in one of a hundred holes. Mice leaving from a stable entrance learned to efficiently navigate to the food without the need for landmarks.

Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.

Characterizing DNA methylation patterns is important for addressing key questions in evolutionary biology, geroscience, and medical genomics. While costs are decreasing, whole-genome DNA methylation profiling remains prohibitively expensive for most population-scale studies, creating a need for cost-effective, reduced representation approaches (i.e.

Boosting reservoir computer performance with multiple delays.

Time delays play a significant role in dynamical systems, as they affect their transient behavior and the dimensionality of their attractors. The number, values, and spacing of these time delays influences the eigenvalues of a nonlinear delay-differential system at its fixed point. Here we explore a multidelay system as the core computational element of a reservoir computer making predictions on its input in the usual regime close to fixed point instability.

Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment.

In a variety of neurons, action potentials (APs) initiate at the proximal axon, within a region called the axon initial segment (AIS), which has a high density of voltage-gated sodium channels (NaVs) on its membrane. In pyramidal neurons, the proximal AIS has been reported to exhibit a higher proportion of NaVs with gating properties that are "right-shifted" to more depolarized voltages, compared to the distal AIS. Further, recent experiments have revealed that as neurons develop, the spatial distribution of NaV subtypes along the AIS can change substantially, suggesting that neurons tune their excitability by modifying said distribution.