Publications by authors named "A Lollert"
: To evaluate correlations between cardiac magnetic resonance imaging (cMRI) at rest including strain imaging and variables derived from quantitative cardiopulmonary exercise testing using a treadmill in patients with pectus excavatum. : We retrospectively correlated the results of cMRI and cardiopulmonary exercise testing in 17 patients with pectus excavatum, in whom both examinations were performed during their pre-operative clinical evaluation. In addition to cardiac volumetry, we assessed the strain rates of both ventricles using a feature-tracking algorithm of a piece of commercially available post-processing software.
View Article and Find Full Text PDF[Lysosomal storage disorders - Fabry disease and Gaucher disease].
Dtsch Med Wochenschr
October 2024
Article Synopsis
- - Lysosomal storage disorders (LSD) are genetic metabolic conditions caused by issues with lysosomes, affecting roughly 1 in 5000 births, with Fabry and Gaucher diseases being the most prevalent
- - These disorders primarily result from enzyme deficiencies, leading to the buildup of undegraded materials in cells, which can disrupt normal cellular function and cause toxicity or inflammation
- - There are approved treatment options for Fabry and Gaucher diseases, including enzyme replacement therapy, chaperone therapy, and substrate reduction therapy.
Objectives: Neonatal MRI is usually performed under deep sedation, which is challenging-especially in low-weight premature patients. In addition, long-term side effects, such as neurotoxicity, are of concern. An alternative to sedation is to induce natural sleep by feeding and immobilising the child, the "feed-and-wrap" technique (FWT).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the early detection of cardiac changes in patients with Fabry's disease (FD), which can lead to serious complications like left ventricular hypertrophy.
- Researchers evaluated biventricular strain assessments in 58 FD patients compared to 62 healthy volunteers using advanced cardiac imaging techniques.
- Findings suggest that biventricular strains can effectively distinguish early FD patients from healthy individuals, potentially allowing for earlier treatment and better long-term outcomes.