Publications by authors named "A Loewe"
Article Synopsis
- * Clinical ERP measurements were taken from seven patients and used to create anatomical atrial models, comparing four different approaches to modeling ERP distributions, including both personalized and non-personalized methods.
- * Results show that incorporating personalized ERP increased arrhythmia inducibility compared to uniform distributions; however, the presence of fibrotic areas altered the dynamics, suggesting that personalized ERP modeling could significantly impact clinical outcomes.
Aims: Patients with persistent atrial fibrillation (AF) experience 50% recurrence despite pulmonary vein isolation (PVI), and no consensus is established for secondary treatments. The aim of our i-STRATIFICATION study is to provide evidence for stratifying patients with AF recurrence after PVI to optimal pharmacological and ablation therapies, through in silico trials.
Methods And Results: A cohort of 800 virtual patients, with variability in atrial anatomy, electrophysiology, and tissue structure (low-voltage areas, LVAs), was developed and validated against clinical data from ionic currents to electrocardiogram.