Sequence Flow: interactive web application for visualizing partial order alignments.

Background: Multiple sequence alignment (MSA) has proven extremely useful in computational biology, especially in inferring evolutionary relationships via phylogenetic analysis and providing insight into protein structure and function. An alternative to the standard MSA model is partial order alignment (POA), in which aligned sequences are represented as paths in a graph rather than rows in a matrix. While the POA model has proven useful in several applications (e.

Mental Health Support in Higher Education during the COVID-19 Pandemic: A Case Study and Recommendations for Practice.

The COVID-19 pandemic has caused changes in the lives of many university students around the globe, including students at Maria Curie-Skłodowska University in Lublin, Poland. Isolation, a sense of threat, and the transition to remote learning resulted in numerous, mainly psychological, negative consequences for students. The university aimed to provide students with effective assistance during the COVID-19 pandemic.

Mood and Emotions among Inmates after COVID-19 Pandemic.

Background: During imprisonment, inmates face many difficulties in adapting to life behind bars. The aim of the study was to find out (a) how challenging for inmates were the selected COVID-19 pandemic-related changes and stressors, (b) what moods and emotions are most commonly experienced by prisoners just after the difficult period of the COVID-19 pandemic, and (c) which of the selected factors determine the positive and negative mood of inmates.

Methods: The research was conducted in July 2022 in six randomly selected Polish prisons.

Linearization of genome sequence graphs revisited.

The need to include the genetic variation within a population into a reference genome led to the concept of a genome sequence graph. Nodes of such a graph are labeled with DNA sequences occurring in represented genomes. Due to double-stranded nature of DNA, each node may be oriented in one of two possible ways, resulting in marking one end of the labeling sequence as in-side and the other as out-side.

[The endocrine mask of a developing process of schizophrenia--case study].

In this research psychic and somatic symptoms related to disturbances of hypothalamus-hypophysis-peripheral regulation which may occur in the schizophrenic process were analysed. Authors discussed the problem of relations between hypothalamus neuroregulation and pathogenesis of endocrine disturbances which suggest the organic cause of obesity, hirsutism and secondary amenorrhea among women diagnosed with paranoid schizophrenia. Actual antipsychotic pharmacological treatment, including some side-effects: the metabolic (obesity) and the endocrine (hyperprolactinemia) ones were considered.