MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome.

P-glycoprotein (PGP), the product of the MDR1 gene, is a transmembrane active efflux pump for a variety of carcinogens and cytostatics. It has been suggested that MDR1 polymorphisms contribute to the variability in cancer risk and therapeutic outcome. We examined the relevance of C3435T polymorphism in relation to breast cancer susceptibility, clinical and pathological characteristics of breast carcinoma, the therapeutic response and hematologic toxicities after anthracycline-based chemotherapy.

Comparison of cation-osmotic haemolysis in normal and low birth weight newborns during the first month of life.

The present study was designed to compare cation-osmotic haemolysis (COH) in normal versus low birth weight newborns during the first month of postnatal life. COH was assessed in 80 normal (NBW) and 45 low birth weight newborns (LBW). A significant decrease in COH in the solutions with low ionic strength (15.

Differences between cation-osmotic hemolysis and filterability in exaprolol- and glutaraldehyde-treated human red blood cells.

The changes in human red blood cell microrheology in different glutaraldehyde (3.0 and 5.0 x 10(-6) mol x l(-1)) and exaprolol (2.

Effect of indomethacin on selected immune parameters in different age groups of mice.

The authors studied the effect of indomethacin on the phagocytic activity of polymorphonuclear leucocytes (PMNL) and on haemolytic antibody formation (plaques) by lymphoid cells of the spleen in 3-, 6- and 12-month-old mice. In 3- and 12-month-old animals the phagocytic activity of the PMNL was significantly inhibited. Plaque formation was likewise significantly inhibited in 3-month-old mice, but it was significantly raised in 6- and 12-month-old animals.

[The effect of exaprolol and sodium salicylate on erythrocyte hemolysis in relation to age].

The effect of exaprolol and sodium salicylate on hemolysis of erythrocytes was studied in dependence on the age of rats. Rats of the Wistar strain were used in the experiment in six different age groups. Exaprolol concentration was in the range from 0.