Patterns of familial transmission of HBV and the risk of developing liver cancer: a case-control study in the Philippines.

The present case-control study was carried out in the Philippines to determine the risk of developing hepatocellular carcinoma (HCC) in relation to different HBV serological profiles of parents and sibs of HCC cases and controls. The HBV serological profiles of parents and sibs of 33 patients with HCC were compared with those of 2 types of community control: 33 general population controls matched for sex and age (C1 controls) and 33 asymptomatic HBsAg carriers also matched for sex and age (C2 controls). When cases were compared with C1 controls, increased risks were associated with the fact of having an HBsAg-positive mother (RR = 2.

Mother to child transmission of hepatitis B virus in the Philippines.

A follow-up study of mother to infant transmission of hepatitis B virus was conducted in the Philippines between 1981 and 1983. The prevalence of HBsAg among 527 mothers was 8.5%.

The relationship of hepatocellular carcinoma and liver cirrhosis to hepatitis B virus infection in the Philippines.

The relationship between hepatitis B virus (HBV) infection and cirrhosis (CIR) and hepatocellular carcinoma (HCC) was investigated. 340 cases with HCC and 99 cases with CIR were compared with the control group which were asymoptomatic age- and sex-matched case. Both HCC and CIR have higher infection rated of HBV and the positivity rated of HBsAg than their controls in both sexes.

A cost-effectiveness analysis of a simple micromethod for hepatitis B screening in hepatitis B virus control programmes.

We developed a simple micromethod for identifying mothers who are most likely to transmit hepatitis B infection to their infants, using reverse passive haemagglutination for detecting HBsAg (hepatitis B surface antigen) in capillary blood. This screening method was evaluated against other strategies for hepatitis B control by means of decision- and cost-effectiveness analyses. The micromethod was shown to be cost-effective when the cost of hepatitis B vaccine was high.

Sero-epidemiological study on hepatitis A and B virus infection among dentists in the Philippines.

Dentists in the Philippines were surveyed for evidence of past hepatitis A and B virus infections. Of the 234 dentists examined, 201 (85.9 per cent) were found to have been infected by HA virus and 137 (58.