Publications by authors named "A Linden Hirschberg"
Article Synopsis
- Kidney diseases are linked to aging and the effects of decreased estrogen due to ovarian senescence, leading to reduced kidney function and increased cardiometabolic risks that can result in chronic kidney disease (CKD).
- CKD can negatively impact ovarian function in women during their reproductive years.
- An individualized menopause management approach for women with CKD includes hormone therapy based on personal preferences and cardiovascular risks, lifestyle modifications, regular monitoring, and tailored guidance for those with additional health issues.
Background: Increased access to and indications for genetic testing will lead to more women undergoing risk-reducing salpingo-oophorectomy (RRSO), with a potential impact on sexual function.
Aim: Our objective was to prospectively investigate (1) sexual function in women with pathogenic variant (PV) in genes, before and 1 year after RRSO, and to compare with a healthy age-matched control group and (2) to study if testosterone levels correlate with sexual functioning after RRSO.
Methods: A prospective observational follow-up study of 43 -PV carriers planned for RRSO and 73 healthy-age matched controls.
Objectives: To assess the efficacy and safety of the non-hormonal, neurokinin 3 receptor antagonist, fezolinetant, to treat moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy.
Design: Phase 3b randomised controlled trial.
Setting: 16 countries.
Introduction: Fear of cancer recurrence (FCR) is prevalent and distressing among survivors of cancer. Evidence-based mind-body and cognitive-behavioral skills lack integration and testing in scalable formats.
Objective: This pilot randomized controlled trial (NCT04876599) tested a synchronous, virtual mind-body group resiliency intervention for FCR (IN FOCUS).
Women with polycystic ovary syndrome (PCOS) have varying difficulties in achieving weight loss by lifestyle intervention, which may depend on adipose tissue metabolism. The objective was to study baseline subcutaneous adipose tissue gene expression as a prediction of weight loss by lifestyle intervention in obese/overweight women with PCOS. This is a secondary analysis of a randomized controlled trial where women with PCOS, aged 18-40 and body mass index (BMI) ≥ 27 were initially randomized to either a 4-month behavioral modification program or minimal intervention according to standard care.
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