MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma.

Photothermal therapy (PTT) is a method for eradicating tumor tissues through the use of photothermal materials and photosensitizing agents that absorb light energy from laser sources and convert it into heat, which selectively targets and destroys cancer cells while sparing healthy tissue. MXenes have been intensively investigated as photosensitizing agents for PTT. However, achieving the selectivity of MXenes to the tumor cells remains a challenge.

Optically Guided High-Frequency Ultrasound Shows Superior Efficacy for Preoperative Estimation of Breslow Thickness in Comparison with Multispectral Imaging: A Single-Center Prospective Validation Study.

Melanoma is the most aggressive form of skin cancer that is known for its metastatic potential and has an increasing incidence worldwide. Breslow thickness, which determines the staging and surgical margin of the tumor, is unavailable at initial diagnosis. Novel imaging techniques for assessing Breslow thickness lack comparative data.

Multi-Loss U-Net Reformulation as an Efficient Solution to the Colony-Forming Unit Counting Problem.

U-Net is undoubtedly the most cited and popularized deep learning architecture in the biomedical domain. Starting with image, volume, or video segmentation in numerous practical applications, such as digital pathology, and continuing to Colony-Forming Unit (CFU) segmentation, new emerging areas require an additional U-Net reformulation to solve some inherent inefficiencies of a simple segmentation-tailored loss function, such as the Dice Similarity Coefficient, being applied at the training step. One of such areas is segmentation-driven CFU counting, where after receiving a segmentation output map one should count all distinct segmented regions belonging to different detected microbial colonies.

Multispectral Imaging Analysis of Skin Lesions in Patients with Neurofibromatosis Type 1.

Neurofibromatosis type 1 (NF1) is a rare disease, affecting around 1 in 3500 individuals in the general population. The rarity of the disease contributes to the scarcity of the available diagnostic and therapeutic approaches. Multispectral imaging is a non-invasive imaging method that shows promise in the diagnosis of various skin diseases.