Publications by authors named "A Liguori"
Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. However, rare naive B cells infrequently participate in immune responses. We investigated how germline-targeting vaccine antigen delivery and adjuvant selection affect priming of exceptionally rare BG18-like HIV broadly neutralizing antibody-precursor B cells (~1 in 50 million) in non-human primates.
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- - Portal hypertension (PH) is a serious complication in liver disease, and endoscopic ultrasound (EUS) is being highlighted as an effective diagnostic tool for its assessment due to its high-resolution imaging capabilities
- - The review found that EUS not only improves PH evaluation but also includes advanced methods like contrast enhancement and shear-wave elastography to assess liver stiffness, making it less invasive compared to traditional techniques
- - Despite its advantages, EUS has limitations such as procedural invasiveness and variability in results, necessitating further research and standardization to enhance its clinical application in managing PH
Article Synopsis
- Environmental factors like food availability and individual traits, particularly maternal age, significantly influence the survival and reproduction of the clonal rotifer Brachionus throughout its life.
- Low food conditions delay reproduction and shift population dynamics towards older maternal ages but do not reduce individual reproductive output.
- Matrix population models revealed that decreased fertility, rather than survival, primarily drives reduced population growth rates under low food conditions, highlighting the complex interactions between individual age, maternal age, and environmental stressors.
Microwaves have been successfully employed in the Lewis acid titanium tetrachloride-assisted synthesis of peptide systems. Dipeptide systems with their amino function differently protected with urethane protecting groups have been synthesized in short periods of time and with high yields. The formation of the peptide bond between the two reacting amino acids was achieved in pyridine by using titanium tetrachloride as a condensing agent and heating the reaction mixture with a microwave reactor.
View Article and Find Full Text PDFBackground: The presence and severity of liver fibrosis are important prognostic variables when evaluating people with chronic hepatitis C (CHC). Although liver biopsy remains the reference standard, non-invasive serological markers, such as the four factors (FIB-4) score and the Forns index, can also be used to stage liver fibrosis.
Objectives: To determine the diagnostic accuracy of the FIB-4 score and Forns index in staging liver fibrosis in people with chronic hepatitis C (CHC) virus, using liver biopsy as the reference standard (primary objective).