Publications by authors named "A Libra"
Baclofen is a common muscle relaxant agent used in a number of neurological disorders acting at central level and potentially causing adverse respiratory events, still largely unknown at therapeutic doses. We present the case of a young woman with spastic tetraparesis secondary to perinatal asphyxia treated with a standard dose of intrathecal baclofen who developed nocturnal symptoms, somnolence and memory loss during the day. Nocturnal cardio-respiratory sleep monitoring showed a high number of central sleep apneas (CSA).
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- The study aimed to identify expanded sequence types (eSTs) of Ureaplasma species from amniotic fluid in pregnancies affected by preterm prelabor rupture of membranes (PPROM) using a multilocus sequence typing scheme.
- It analyzed DNA samples from singleton pregnancies between 24 to 36 weeks gestation and discovered a total of 33 different eSTs, with 21 being novel, while the most common eST was found in 18% of the samples.
- The research categorized Ureaplasma DNA into two clusters, revealing that cluster II (U. urealyticum) had a higher rate of polymicrobial findings compared to cluster I (U. parvum), but there were
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- This study investigates the characteristics and treatment outcomes of patients with non-tuberculous mycobacteria (NTM) diseases at a hospital in Catania, Italy, focusing on demographics and treatment effectiveness.
- The research involved a retrospective analysis of 10 diagnosed patients from 2019 to 2021, collecting data on their demographics, comorbidities, treatment methods, and outcomes using descriptive statistics.
- Results showed that all patients were female with a median age of 55.44 years, predominantly affected by pulmonary diseases; despite all achieving microbiological cures, 60% showed clinical improvement, highlighting the need for tailored treatment strategies and further research on NTM management.
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible scarring of lung tissue, leading to death. Despite recent advancements in understanding its pathophysiology, IPF remains elusive, and therapeutic options are limited and non-curative. This review aims to synthesize the latest research developments, focusing on the molecular mechanisms driving the disease and on the related emerging treatments.
View Article and Find Full Text PDFIdiopathic pulmonary fibrosis (IPF) represents a fibrotic interstitial lung disease characterized by uncertain etiology and poor prognosis. Over the years, the path to effective treatments has been marked by a series of advances and setbacks. The introduction of approved antifibrotic drugs, pirfenidone and nintedanib, marked a pivotal moment in the management of IPF.
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