Publications by authors named "A Lespagnol"
Article Synopsis
- - The study investigates the role of TCTP (translationally controlled tumor protein) in regulating oncogenic intercellular signaling through extracellular vesicles (EVs), particularly in response to genotoxic stress.
- - Researchers used a Tctp-inducible knockout mouse model and found that TCTP is crucial for triggering apoptosis signaling and promoting malignant growth via small EVs (sEVs).
- - The findings suggest that TCTP enhances tumor development by binding to DDX3 and recruiting RNAs, including miRNAs, to sEVs, and inhibiting TCTP can improve survival rates in tumor-prone mice.
Mismatch repair deficiency (d-MMR)/microsatellite instability (MSI), , and mutational status are crucial for treating advanced colorectal cancer patients. Traditional methods like immunohistochemistry or polymerase chain reaction (PCR) can be challenged by artificial intelligence (AI) based on whole slide images (WSI) to predict tumor status. In this systematic review, we evaluated the role of AI in predicting MSI status, , and mutations in colorectal cancer.
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- BRCA1 and BRCA2 genes are essential for repairing DNA damage, and their mutations can predict how sensitive high-grade ovarian cancer (HGOC) is to certain treatments, but current testing methods are expensive and slow.
- This study introduces a deep learning classifier that predicts BRCA mutations using whole slide images of HGOC, developed from a substantial patient cohort, and shows promise in increasing efficiency and accuracy in testing.
- The classifier achieved high performance metrics, suggesting that it can effectively detect phenotypic changes linked to BRCA mutations, making it a potential prescreening tool for future use.
Accurate testing for epidermal growth factor receptor () variants is essential for informing treatment decisions in non-small cell lung cancer (NSCLC). Automated diagnostic workflows may allow more streamlined initiation of targeted treatments, where appropriate, while comprehensive variant analysis is ongoing. FACILITATE, a real-world, prospective, multicenter, European study, evaluated performance and analytical turnaround time of the Idylla™ EGFR Mutation Test compared with local reference methods.
View Article and Find Full Text PDFBackground: Low miR-31-3p expression was identified as predictive of anti-EGFR efficacy in RAS-wt mCRC. Primary tumor side was also proposed as a predictive factor of anti-EGFR benefit. This retrospective multicentric study evaluated the predictive role of miR-31-3p in right-sided RAS-wt mCRC patients treated with first-line CT+anti-EGFR or CT+bevacizumab (Beva).
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