Stimulation of the ventromedial prefrontal cortex and the perception of affective faces. An effective connectivity analysis.

The ventromedial prefrontal cortex is widely linked with emotional phenomena, including appraisal, modulation, and reward processing. Its perigenual part is suggested to mediate the appetitive value of stimulation. In our previous study, besides changes in evoked MEG responses, we were able to induce an apparent behavioral bias toward more positive valence while interpreting the ambiguous, morphed faces after the effect of excitatory tDCS stimulation of the perigenual ventromedial cortex (pgVM).

Binary progenitor systems for Type Ic supernovae.

Core-collapse supernovae are explosions of massive stars at the end of their evolution. They are responsible for metal production and for halting star formation, having a significant impact on galaxy evolution. The details of these processes depend on the nature of supernova progenitors, but it is unclear if Type Ic supernovae (without hydrogen or helium lines in their spectra) originate from core-collapses of very massive stars (>30 M) or from less massive stars in binary systems.

Seven-membered N-heterocycles as approved drugs and promising leads in medicinal chemistry as well as the metal-free domino access to their scaffolds.

Azepanes or azepines are structural motifs of many drugs, drug candidates and evaluated lead compounds. Even though compounds having N-heterocyclic 7-membered rings are often found in nature (e.g.

Inhibition of the dorsolateral cortex reveals specific mechanisms behind emotional control.

Reappraisal is a complex emotional control strategy based on cognitive change. To complete the reappraisal task, one is required to deeply elaborate on the affective stimulus to create its new interpretation. The involvement of the prefrontal cortex in this process was examined in the study, where inhibition of the left or right dorsolateral area was carried out using transcranial magnetic stimulation.

Development of an SPRi Test for the Quantitative Detection of Cadherin 12 in Human Plasma and Peritoneal Fluid.

A new method for the determination of cadherin 12 (CDH12)-an adhesive protein that has a significant impact on the development, growth, and movement of cancer cells-was developed and validated. The method is based on a biosensor using surface plasmon resonance imaging (SPRi) detection. A quartz crystal microbalance was used to analyze the characteristics of the formation of successive layers of the biosensor, from the linker monolayer to the final capture of CDH12 from solution.