Publications by authors named "A Lesniak"
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver tissue collected before initiating IS weaning.
View Article and Find Full Text PDFThe psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT receptor activation and serotonergic transmission.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
The antidepressant-like activity of two psychoplastogens, ibogainalog (IBG) and ibogaminalog (DM506), was studied in naïve mice using the forced swim test (FST) and tail suspension test (TST). The behavioral results showed that a single administration of 25 mg/kg DM506 or 10 mg/kg IBG induced antidepressant-like activity in naïve mice in a volinanserin-sensitive manner that persisted for 72 h. Similar results were observed using the chronic immobilization stress (CIS) test, in which depression symptoms were reduced for 48 h.
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- * Research on heart transplants with mismatched MHC class II revealed that graft-derived IL-33 activates tissue repair pathways in Tregs and macrophages, with a notable impact from regulating amphiregulin (Areg) expression.
- * Deleting Areg specifically in Tregs indicated that Areg promotes chronic rejection through increased fibroblast growth, suggesting that the interplay between IL-33 from fibroblasts and Tregs is crucial for advancing CR in transplanted organs.
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- In a study on phenylketonuria (PKU), data from 1323 patients across nine European and Turkish centers revealed that natural protein intake rises with age, especially during childhood and adolescence, while lifelong phenylalanine tolerance remains unclear.
- The research collected dietary intake information from 2012 to 2018, showing varying tolerances among different PKU classifications, with patients having mild PKU tolerating about 50% more phenylalanine than those with classical PKU.
- Additionally, the study highlighted that natural protein intake significantly increased for patients using sapropterin, with notable geographical differences in protein tolerance observed between Southern and Northern Europe.
Spinal muscular atrophy with respiratory distress type 1 (SMARD1; OMIM #604320, ORPHA:98920) is a rare autosomal recessive congenital motor neuron disease. It is caused by variants in the gene. Clinically, it presents with respiratory failure due to diaphragmatic paralysis, progressive muscle weakness starting in the distal parts of the limbs, dysphagia, and damage to sensory and autonomic nerves.
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