Publications by authors named "A Lesiak"
This comprehensive review explores the pivotal roles of glycation and oxidative stress in the aging process of the skin, emphasizing their targeted therapeutic applications in aesthetic and regenerative medicine, as well as anti-aging interventions. Glycation, a biochemical process involving the non-enzymatic attachment of sugars to proteins, lipids, or nucleic acids, culminates in the formation of Advanced Glycation End products (AGEs). These AGEs are significant contributors to aging and various chronic ailments, triggering oxidative stress and inflammatory pathways, thereby manifesting as wrinkles, diminished skin elasticity, and other age-related dermal alterations.
View Article and Find Full Text PDFIntroduction: Chronic pruritus is one of the most common symptoms in geriatric patients. Pathogenesis of pruritus is multifactorial.
Aim: To evaluate the prevalence and characteristics of pruritus in geriatric patients and to characterise pruritus and explore its possible underlying causes.
Introduction: Despite multiple clinical presentations of long COVID, the most common symptom encountered by the patients is fatigue which significantly impacts daily functioning and quality of life. There are, however, multiple unanswered questions regarding the treatment of fatigue among long COVID patients. Several studies highlighted that repetitive exposure to blue light may alleviate the fatigue in different groups of patients but the studies on the efficacy of blue light therapy in treatment of fatigue in long COVID patients are lacking.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the demographic and clinical traits of Polish patients with generalized pustular psoriasis (GPP), revealing that most patients are middle-aged women with common comorbidities like hypertension and cardiovascular diseases.
- A total of 90 patients were examined, who had a median GPP duration of 3 years and experienced an average of 2 flares, often requiring hospitalization; main triggers for flares included medications and infections.
- The findings showed significant differences, such as younger patients often having GPP alongside psoriasis vulgaris (PV), highlighting a need for better management due to the high hospitalization rate and recurrent flares.