Publications by authors named "A Lepape"
Background: While SARS-CoV2 infection has been shown to be a significant risk-factor for several secondary bacterial, viral and Aspergillus infections, its impact on intensive care unit (ICU)-acquired candidemia (ICAC) remains poorly explored.
Method: Using the REA-REZO network (French surveillance network of ICU-acquired infections), we included all adult patients hospitalized for a medical reason of admission in participating ICUs for at least 48 h from January 2020 to January 2023. To account for confounders, a non-parsimonious propensity score matching was performed.
Purpose: We aim to evaluate the association between central venous catheter (CVC) insertion site and microbiological CVC complications in a nationwide cohort.
Methods: This study was conducted using the healthcare-associated infection surveillance cohort "REA-REZO" involving 193 intensive care units (ICUs). All CVC inserted and removed during the same ICU stay between January 1st 2018 and December 31st 2022 were eligible but only those whose tips were sent for microbiological analysis were included.
Article Synopsis
- - Candidemia is a serious risk for ICU patients, and this study examines how selective digestive decontamination (SDD) might affect its occurrence amidst patients on mechanical ventilation.
- - Data from nearly 94,500 patients was analyzed, revealing that those treated with SDD had a significantly lower incidence of ICU-acquired candidemia compared to those receiving standard care.
- - Despite the reduction in the rate of candidemia, there was no notable difference in survival rates or length of ICU stay between SDD-treated patients and those who did not receive SDD.
Purpose: Septic shock is associated in some patients with a profound immunosuppression. We hypothesized that GM-CSF would reduce the occurrence of ICU-acquired infections in immunosuppressed septic patients.
Methods: Randomized double-blind trial conducted between 2015 and 2018.