Publications by authors named "A Lemy"
Background: Clinical risk factors of deficient immune responses to COVID-19 mRNA vaccination in SARS-CoV-2 naive hemodialysis recipients (HDR) have already been identified. Clinical factors influencing hybrid immunity induced by SARS-CoV-2 infection and vaccination in HDR have not been reported.
Methods: A comprehensive analysis of antibody (Ab) and T cell responses to two doses of BNT162b2 mRNA vaccination was performed in 103 HDR, including 75 SARS-CoV-2 naive and 28 experienced patients, and in 106 healthy controls (HC) not undergoing HD, including 40 SARS-CoV-2 naive and 66 experienced subjects.
Article Synopsis
- Comorbidities and immunosuppressive treatments decrease immune responses to COVID-19 mRNA vaccines in kidney transplant recipients (KTRs), particularly in those who have never been infected with SARS-CoV-2 (naïve KTRs).
- A study of 82 KTRs showed that those previously infected with SARS-CoV-2 (experienced KTRs) had vaccine responses similar to healthy controls, while naïve KTRs had significantly lower responses linked to factors like age and type of immunosuppressive therapy.
- The findings suggest that hybrid immunity (prior infection plus vaccination) effectively counteracts immune suppression in KTRs, enhancing both antibody and cellular responses against
As solid organ transplant recipients are at high risk of severe COVID-19 and respond poorly to primary SARS-CoV-2 mRNA vaccination, they have been prioritized for booster vaccination. However, an immunological correlate of protection has not been identified in this vulnerable population. We conducted a prospective monocentric cohort study of 65 kidney transplant recipients who received 3 doses of BNT162b2 mRNA vaccine.
View Article and Find Full Text PDFBackground: Patients undergoing kidney transplantation are sometimes being treated with antiplatelet agents such as ticlopidine or clopidogrel. Some teams refuse to wait-list these patients for fear of bleeding during transplant surgery.
Methods: We retrospectively reviewed the records of 702 adult patients with a kidney transplant alone between 2000 and 2010.