Publications by authors named "A Leis"
Background: The objective of this study was to determine whether postoperative pager alerts to the Hospital Elder Life Program (HELP), a delirium prevention service, would accelerate program enrollment for older surgical patients. This study also tested feasibility of family care partner interventions for delirium prevention.
Methods: This single-center, pilot clinical trial factorially randomized 57 non-cardiac surgical patients ≥70 years of age to 4 arms: (1) standard care, (2) pager alerts to accelerate HELP enrollment, (3) family care partner-based delirium prevention interventions, or (4) a combined arm with both HELP and family interventions.
Purpose: The generation of representative disease phenotypes is important for ensuring the reliability of the findings of observational studies. The aim of this manuscript is to outline a reproducible framework for reliable and traceable phenotype generation based on real world data for use in the Data Analysis and Real-World Interrogation Network (DARWIN EU). We illustrate the use of this framework by generating phenotypes for two diseases: pancreatic cancer and systemic lupus erythematosus (SLE).
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- Test-negative design (TND) studies are essential for monitoring the effectiveness of influenza vaccines, but the emergence of vaccines for SARS-CoV-2 and RSV complicates the analysis due to the need for appropriate control selection.
- A simulation study and secondary analysis of TND estimates from Southeast Michigan showed that RSV prevalence among control groups could potentially bias influenza vaccine effectiveness results, especially when RSV is vaccine-preventable.
- However, the actual analysis indicated that including RSV cases in the control group did not significantly affect the effectiveness estimates for influenza vaccines, suggesting that current biases are minimal when RSV is not vaccine-preventable.
Tendon entrapment is a rare complication of closed forearm fractures. A 16-year-old boy sustained a type 1 open both bone forearm fracture after falling from a skateboard. The injury was initially managed with irrigation, debridement, and flexible intramedullary nailing.
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