Publications by authors named "A Leggieri"
The reproducibility crisis in bioscience, characterized by inconsistent study results, impedes our understanding of biological processes and global collaborative studies offer a unique solution. This study is the first global collaboration using the zebrafish () novel tank test, a behavioral assay for anxiety-like responses. We analyzed data from 20 laboratories worldwide, focusing on housing conditions and experimental setups.
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- RBFOX1 plays a key role in regulating transcriptional networks involved in synaptic transmission and neurodevelopment, impacting psychiatric disorder vulnerability.
- Dysfunction of RBFOX1 affects the alternative splicing of PAC1 and disrupts the BDNF/TrkB pathway, which is vital for neuroplasticity and resilience to stress.
- Using a zebrafish model, researchers found that RBFOX1 loss of function leads to hyperactivity and other behavioral issues, highlighting its crucial role in HPA axis regulation during development and its potential link to psychiatric disorders.
RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been associated with several psychiatric conditions, but the mechanisms underlying the pleiotropic effects of RBFOX1 are not yet understood. Here we found that, in zebrafish, rbfox1 is expressed in spinal cord, mid- and hindbrain during developmental stages.
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- The gene being studied is linked to various psychiatric and neurodevelopmental disorders, but how it causes these issues remains unclear.
- In zebrafish, the gene shows specific expression patterns during development and in adult brains, indicating its role in sensory processing and behavior.
- Deficiency in this gene leads to behavioral changes in zebrafish, such as hyperactivity and altered social interactions, suggesting similarities with traits seen in mice and humans with psychiatric disorders, highlighting the need for further research on its functions.
Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription factors. Genetic variation within the locus is suggested to play a role in vulnerability to addictions. However, mechanism of action is still poorly understood.
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