Publications by authors named "A Leccese"
The impact of soil fertilization with animal manure on the spread and persistence of antibiotic resistance in the environment is far from being fully understood. To add knowledge about persistence and correlations between antibiotic residues and antibiotic resistance genes (ARGs) in fertilized soil, a longitudinal soil mesocosm study was conducted. Soil samples were collected from the mesocosms immediately before spreading and then afterward at fifteen time points during a 320-day observation period.
View Article and Find Full Text PDFBackground: In the recent years, there was an important improvement in the understanding of the pathogenesis of hereditary angioedema (HAE). Notwithstanding, in a large portion of patients with unknown mutation (HAE-UNK) the genetic cause remains to be identified.
Objectives: To identify new genetic targets associated with HAE, a large Argentine family with HAE-UNK spanning 3 generations was studied.
Article Synopsis
- - Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and features different molecular subtypes, particularly the basal-like subtype, which shows increased resistance to chemotherapy.
- - The study identifies a specific splicing signature tied to PDAC subtypes and highlights the splicing factor Quaking (QKI) as crucial for the basal-like characteristics and worse patient outcomes.
- - QKI promotes splicing events that enhance the aggressive, adaptable traits of PDAC cells, contributing to their ability to migrate and resist chemotherapy, especially in high-grade tumors and metastases.
The ZIP (Zrt and Irt-like proteins) protein family includes transporters responsible for the translocation of zinc and other transition metals, such as iron and cadmium, between the extracellular space (or the lumen of organelles) and the cytoplasm. This protein family is present at all the phylogenetic levels, including bacteria, fungi, plants, insects, and mammals. ZIP proteins are responsible for the homeostasis of metals essential for the cell physiology.
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