Publications by authors named "A Leander Fontaine"
Purpose: To identify molecular changes during PCa invasion of adipose space using Spatial Transcriptomic Profiling of PCa cells.
Methods: This study was performed on paired intraprostatic and extraprostatic samples obtained from radical prostatectomy with pT3a pathological stages.
Results: Differential gene expression revealed upregulation of heat shock protein genes: DNAJB1, HSPA8, HSP90AA1, HSPA1B, HSPA1A in PCa PanCK+ cells from the adipose periprostatic space.
Background: The risk of mosquito-borne disease transmission is increasing in temperate climates with the colonization and proliferation of the Asian tiger mosquito vector Aedes albopictus and the rapid mass transport of passengers returning from tropical regions where viruses are endemic. The prevention of major Aedes-borne viruses heavily relies on the use of insecticides for vector control, mainly pyrethroids. In Europe, only deltamethrin is authorized.
View Article and Find Full Text PDFWest Nile Virus (WNV) and Usutu virus (USUV) circulate through complex cryptic transmission cycles involving mosquitoes as vectors, birds as amplifying hosts and several mammal species as dead-end hosts. Both viruses can be transmitted to humans through mosquito bites, which can lead to neuroinvasive and potentially fatal disease. Notably, WNV can also be transmitted through blood donations and organ transplants.
View Article and Find Full Text PDFArticle Synopsis
- - Red wolves are critically endangered, with over 95% living in human care, and gastrointestinal (GI) disease is a major cause of death among them.
- - The study analyzed data from 36 adult red wolves between 2004 and 2022, finding that a diet consisting only of kibble was linked to more severe GI mucosal disease compared to those fed whole prey or meat.
- - It also found that red wolves treated with nonsteroidal anti-inflammatory drugs had worse GI health, while factors like housing and life history had no significant impact.